ABSTRACT
Objectives: To assess intelligence Quotient (IQ) in transfusion dependent ?-thalassemia major patients using Malin Intelligence Scale for Indian Children (MISIC) and to correlate verbal IQ (VIQ), performance IQ (PIQ) and full scale IQ (FSIQ) with serum ferritin levels and annual blood transfusion requirements. Methods: Cross-sectional study design, enrolling 100 patients of transfusion-dependent ?-thalassemia aged 6 years to 15 years 11 months. IQ was assessed using MISIC. Results: Mean (SD) full scale IQ was 95.96 (7.23). IQ was ‘average’ in most of the patients. There was a significant negative correlation of serum ferritin levels with object assembly (r=-0.215, P=0.034) component of PIQ; annual blood requirement with general comprehension component of VIQ (r=-0.275, P=0.006) and age at diagnosis with PIQ (r=-0.273, P=0.006). There was a significant linear correlation of PIQ (r=0.280, P=0.005) and FSIQ (r=0.274, P=0.006) with pre-transfusion hemoglobin. Conclusion: IQ correlates with age at diagnosis and average annual pre-transfusion hemoglobin. This highlights the importance of early diagnosis and maintenance of satisfactory hemoglobin levels
ABSTRACT
Aims & Objectives: This study aimed to describe the prevalence of the various lesions and to characterize imaging features of the sellar and parasellar lesions and to correlate between clinical and radiological diagnosis. Methodology: This study was done for the characterization of sellar & parasellar lesions with the help of MRI scan, which were done at the MRI centre, MB Hospital, Udaipur, Rajasthan from January 1, 2017, to December 2017. Medical case papers were reviewed for the primary clinical indication that led to a referral for pituitary MRI and serum prolactin levels were noted to follow up regarding surgical or conservative management was done. After analyzing the data results were expressed as frequency of occurrence and percentages of various lesions which were compared with clinical findings. Results: The study population consisted of 80 patients, of which majority were females. MRI revealed abnormality in 68% cases and it was found that combined sellar and suprasellar involvement was there in most of the patients, followed by pure intrasellar and parasellar involvement. Conclusion: The sellar and parasellar regions can be affected by a wide variety of lesions with almost similar presentation. When symptoms of mass effect, visual field deficits and endocrine abnormalities are not sufficient to distinguish these lesions, the use of MRI can helpful in reaching the proper diagnosis